New York  (AP)  Penny Marshall, who indelibly starred in the top rated sitcom “Laverne & Shirley” before becoming the trailblazing director of smash hit big screen comedies such as “Big” and “A League of Their Own,” has died. She was 75.

Michelle Bega, a spokeswoman for the Marshall family, said Tuesday that Marshall died in her Los Angeles home on Monday night due to complications from diabetes. Marshall earlier fought lung cancer, which went into remission in 2013. “Our family is heartbroken,” the Marshall family said in a statement.

In “Laverne & Shirley,” among television’s biggest hits for much of its eight-season run between 1976-1983, the nasal-voiced, Bronx-born Marshall starred as Laverne DeFazio alongside Cindy Williams as a pair of blue-collar roommates toiling on the assembly line of a Milwaukee brewery. A spinoff of “Happy Days,” the series was the rare network hit about working-class characters, and its self-empowering opening song (“Give us any chance, we’ll take it/ Read us any rule, we’ll break it”) foreshadowed Marshall’s own path as a pioneering female filmmaker in the male-dominated movie business.